Further Reading

Using Old Drugs To Treat COVID-19? Protein Interaction Map Targets Sigma Receptors | FPS#14

Dr. David Gordon, Associate Professor at the University of California San Francisco joins us to speak about the recent manuscript published in the journal Nature. An international effort by a team of over 120 scientists, they developed a protein interaction map showing that the virus can bind to at least 332 human proteins to enter our cells to spread infection. The study demonstrates that 69 existing drugs (FDA approved or in pre-clinical development) harbor the structure and function needed to block COVID from infecting the cell, stop it’s progression, or both. Open access article link: https://www.nature.com/articles/s4158…

SARS-COV-2 cadaver article published May 13, 2020 addendum: https://www.nejm.org/doi/full/10.1056…

How Nicotine Primes The Teenage Brain For Depression & Anxiety In Adulthood (Biomarkers) | FPS#11

Which biomarkers are linked to depression and anxiety following nicotine exposure? Although nicotine vapour may be less harmful to overall health than tobacco smoke, a wealth of research identifies that nicotine exposure during adolescence or teenage years dramatically increases the risk for later mental health disorders including depression and anxiety, independent of whether the individual continues to use nicotine products later into adulthood. These largely overlooked mental health consequences to later life, as well as potential negative outcomes for multiple generations on offspring of the nicotine user amount to largely unknown consequences of adolescent nicotine exposure. In this episode, Roger Hudson joins asked to speak about his recent manuscript exploring the presence of persistent mood and anxiety disorders following nicotine exposure throat adolescence, published in the Journal Addiction Biology. Manuscript Link: https://onlinelibrary.wiley.com/doi/a…

Your Brain In THC Vapor Clouds | Brain Waves In Cannabis Use & Psychosis | FPS#10

Manuscript: Published in the Canadian Journal of Addiction: https://journals.lww.com/cja/Abstract…

How Tiny Touch Tablets For Mice Treat Alzheimer’s | Big Data in Neuroscience | FPS#9

Manuscript: MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment. Published in eLife. Open Access Article: https://elifesciences.org/articles/49630

How Drug Related Cues Improve Memory | Why Addiction Is So Memorable. FPS#8

Manuscript: Modulation of object memory consolidation by Heroin and Heroin-conditioned stimuli: Role of opioid and noradrenergic systems. Published in the journal European Neuropsychopharmacology: https://www.ncbi.nlm.nih.gov/pubmed/3…

Microglial Phagocytosis & Brain Inflammation Are Controlled By Nitric Oxide & TRPV2 | FPS#7

In this episode, we discuss the mechanisms that regulate microglia phagocytosis (such as TRPV2 and other vanilloid receptors) – AKA eating apoptosis ready cells – and how the brain maintains healthy function in aging and after injury, such as traumatic brain injury (TBI).Because neurons get all the attention, you don’t hear too much about glia. Although glia cells DO NOT carry nerve impulses (action potentials) they do have many important functions. In fact, without glia, the neurons would not work properly! Neuroscience PhD Candidates Matthew Maksoud and Viki Tellios join us to speak on their article – Nitric Oxide Upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane – published in the journal Glia: https://onlinelibrary.wiley.com/doi/f…

How The EndoCannabinoid System Controls Stress And Anxiety | Cannabinoid Tone In The Brain | FPS #6

In this episode, Dr. David Marcus – A recent graduate of the Neuroscience PhD Program at Vanderbilt University & 1st author of this episode’s manuscript – joins us to speak about the recently published manuscript, “Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening”, published in the journal Neuron. https://www-sciencedirect-com.proxy1….

Solving Cannabis Hyperemesis Syndrome | How Cannabinoids Regulate Nausea | FPS#5

Why do cannabinoids in cannabis cause nausea and vomiting in some people but not others? Is this limited to heavy users, Recreational users, medicinal cannabis patients? In this episode, FPS ventures into the unknown on the very under-researched area of Cannabinoid Hyperemesis Syndrome. In this episode neuroscience PhD candidate Marieka Devuono joins us to speak about her recently published manuscript that addresses these controversial concepts, entitled “Conditioned gaping produced by high dose Δ9-tetrahydracannabinol: Dysregulation of the hypothalamic endocannabinoid system”, published in Neurophamacology [2018 Oct;141:272-282. doi: 10.1016/j.neuropharm.2018.08.039]. Link: https://linkinghub.elsevier.com/retri…

Depression Biomarkers To Improve Antidepressants | Precision Medicine For Depression | FPS#4

In this episode neuroscience PhD candidate, Stephen Daniels, joins us to speak about his recently published manuscript that addresses these controversial concepts, entitled “Reverse Translation of Major Depressive Disorder Symptoms: A Framework for the Behavioural Phenotyping of Putative Biomarkers”, published in The Journal of Affective Disorders [2020 Feb; 263(15): 353-366] / DOI: 10.1016/j.jad.2019.11.108. https://www.sciencedirect.com/science…

Fight Or Flight In The Amygdala | Experiential Learning Psychology Of Males Vs. Females | FPS#3

“S*ex Differences in Foraging Rats to Naturalistic Aerial Predator Stimuli”, published in iScience from CellPress [Volume 16, 28 June 2019, Pages 442-452] / DOI:10.1016/j.isci.2019.06.011. Open Access Article link: https://www.sciencedirect.com/science…

How Does CBD Block Side Effects of THC? | Highs & Lows of Potent Cannabis Use. FPS #2

“Cannabidiol (CBD) Counteracts the Psychotropic Side-Effects of Delta-9-Tetrahydrocannabinol (THC) in the Ventral Hippocampus through Bidirectional Control of ERK1–2 Phosphorylation”, published in The Journal of Neuroscience [2019 Oct;39(44):8762–8777] / DOI:10.1523/JNEUROSCI.0708-19.2019. https://www.ncbi.nlm.nih.gov/pubmed/3…

How Scientists Are Increasing Antidepressant Effectiveness To Better Treat Depression. FPS #1

“Effects of combined escitalopram and aripiprazole in rats: role of the 5-HT1a receptor”, published in Psychopharmacology [2019 Jul;236(7):2273-2281] / DOI:10.1007/s00213-019-05225-z. https://link.springer.com/article/10….